About CellAura

CellAura fluorescent ligands are part of the Hello Bio range and comprise of innovative fluorescent screening products for life science research and drug discovery.

CellAura combines world-renowned expertise in synthetic chemistry and molecular pharmacology to produce high quality fluorescent reagents as tracers for G-protein coupled receptors (GPCRs) and other common drug discovery target classes.

Our functionally-validated fluorescent compounds comprise well-characterised drug-like molecules linked to standard fluorophore dyes. The resulting fluorescent antagonists and agonists are used for:

  • Confocal Microscopy
    • Localise receptor distribution in tissue sections, cell cultures and single cells
  • High Content Screening
    • Live cell imaging of receptor-ligand binding, displacement, and receptor internalisation
  • Fluorescence Correlation Spectroscopy (FCS)
    • Real-time analysis of single molecule ligand-receptor interactions
  • Fluorescent Ligand Binding
    • Increased safety, reduced disposal cost and environmental impact vs radioligand binding
  • Ligand Binding Kinetics
    • Real-time analysis of ligand association and dissociation to determine receptor affinity
  • Fluorescence Activated Cell Sorting (FACS)
    • No need to generate fluorescence-tagged receptor antibodies, select receptor expressing cells using a direct receptor-binding ligand
  • Dual readout Binding and Function, e.g. Ca++ signalling
    • Distinguishes agonists, antagonists/inverse agonists, off-target effects and non-binders in one assay, to eliminate false hits and reduce follow-on screening
  • High Throughput Screening
    • Dynamic or endpoint binding and displacement Fluorescence Intensity assays