About Us
CellAura Technologies is the premier source of innovative fluorescent screening products for life science research and drug discovery.
CellAura combines world-renowned expertise in synthetic chemistry and molecular pharmacology to produce high quality fluorescent reagents as tracers for G-protein coupled receptors (GPCRs) and other common drug discovery target classes.
Our functionally-validated fluorescent compounds comprise well-characterised drug-like molecules linked to standard fluorophore dyes. The resulting fluorescent antagonists and agonists are used for:
- Confocal Microscopy
- Localise receptor distribution in tissue sections, cell cultures and single cells
- High Content Screening
- Live cell imaging of receptor-ligand binding, displacement, and receptor internalisation
- Fluorescence Correlation Spectroscopy (FCS)
- Real-time analysis of single molecule ligand-receptor interactions
- Fluorescent Ligand Binding
- Increased safety, reduced disposal cost and environmental impact vs radioligand binding
- Ligand Binding Kinetics
- Real-time analysis of ligand association and dissociation to determine receptor affinity
- Fluorescence Activated Cell Sorting (FACS)
- No need to generate fluorescence-tagged receptor antibodies, select receptor expressing cells using a direct receptor-binding ligand
- Dual readout Binding and Function, e.g. Ca++ signalling
- Distinguishes agonists, antagonists/inverse agonists, off-target effects and non-binders in one assay, to eliminate false hits and reduce follow-on screening
- High Throughput Screening
- Dynamic or endpoint binding and displacement Fluorescence Intensity assays